Contact (Jan 2023)

Extending the Contacts Breaks the Flow

  • Amado Carreras-Sureda,
  • Christopher Henry,
  • Nicolas Demaurex

DOI
https://doi.org/10.1177/25152564221125045
Journal volume & issue
Vol. 6

Abstract

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In this news and views, we discuss our recent publication where we described how ER-PM membrane contact sites (MCS) are modulated during store operated calcium entry (SOCE). We also examine why enforcing ER-PM MCS by tethering proteins does not not enhance, but rather inhibits SOCE.