Nature Communications (Sep 2021)
A prostate-specific membrane antigen activated molecular rotor for real-time fluorescence imaging
- Jingming Zhang,
- Anastasia Rakhimbekova,
- Xiaojiang Duan,
- Qingqing Yin,
- Catherine A. Foss,
- Yan Fan,
- Yangyang Xu,
- Xuesong Li,
- Xuekang Cai,
- Zsofia Kutil,
- Pengyuan Wang,
- Zhi Yang,
- Ning Zhang,
- Martin G. Pomper,
- Yiguang Wang,
- Cyril Bařinka,
- Xing Yang
Affiliations
- Jingming Zhang
- Department of Nuclear Medicine, Peking University First Hospital
- Anastasia Rakhimbekova
- Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV
- Xiaojiang Duan
- Department of Nuclear Medicine, Peking University First Hospital
- Qingqing Yin
- State Key Laboratory of Natural and Biomimetic Drugs, Peking University
- Catherine A. Foss
- Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine
- Yan Fan
- Department of Nuclear Medicine, Peking University First Hospital
- Yangyang Xu
- Department of Urology, Peking University First Hospital
- Xuesong Li
- Department of Urology, Peking University First Hospital
- Xuekang Cai
- Department of Nuclear Medicine, Peking University First Hospital
- Zsofia Kutil
- Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV
- Pengyuan Wang
- Department of General Surgery, Peking University First Hospital
- Zhi Yang
- Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/ Beijing), Department of Nuclear Medicine, Peking University Cancer Hospital & Institute
- Ning Zhang
- Translational Cancer Research Center, Peking University First Hospital
- Martin G. Pomper
- Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine
- Yiguang Wang
- State Key Laboratory of Natural and Biomimetic Drugs, Peking University
- Cyril Bařinka
- Institute of Biotechnology of the Czech Academy of Sciences, BIOCEV
- Xing Yang
- Department of Nuclear Medicine, Peking University First Hospital
- DOI
- https://doi.org/10.1038/s41467-021-25746-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Detection of the tumour boundary in prostate cancer is required for surgery. Here the authors present a fluorescent molecular rotor probe to target a prostate cancer marker, prostate-specific membrane antigen (PSMA), which they use in a xenograft mouse model to show it can be used for in vivo imaging.
