Pharmacological efficacy study of the cardio-cerebral stasis transforming medicines on cerebral ischemia and myocardial infarction in rats
Ruilian Liu,
Yangchu Chen,
Xili Zhang,
Yuhan Cai,
Shuang Xu,
Qian Xu,
Xin Li,
Wenjiao Li,
Pingan Liu,
Wenlong Liu
Affiliations
Ruilian Liu
Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China; The Hospital Affiliated to Hunan Academy of Chinese Medicine, Changsha, 410006, Hunan Province, PR China; Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China
Yangchu Chen
Beijing Jianhua Research Institute of Medicine, Beijing, 100000, PR China
Xili Zhang
Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China; Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China
Yuhan Cai
Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China; Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China
Shuang Xu
The Hospital Affiliated to Hunan Academy of Chinese Medicine, Changsha, 410006, Hunan Province, PR China
Qian Xu
The Hospital Affiliated to Hunan Academy of Chinese Medicine, Changsha, 410006, Hunan Province, PR China
Xin Li
Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China
Wenjiao Li
Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China; Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China
Pingan Liu
Hunan Academy of Chinese Medicine, Changsha, 410017, Hunan Province, PR China; Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China; Corresponding author. Hunan Academy of Chinese Medicine, Changsha, 410017, Hunan Province, PR China.
Wenlong Liu
Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China; Hunan Key Laboratory of Druggability and Preparation Modification for Traditional Chinese Medicine, Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China; Corresponding author. Hunan University of Chinese Medicine, Changsha, 410208, Hunan Province, PR China.
The purpose of this study was to investigate the efficacy and mechanisms of cardio-cerebral stasis transforming medicines (CCSTM) against cerebral infarction (CI) and myocardial infarction (MI). CI modeling was conducted using the refined Longa suture-occluded technique, while MI modeling was accomplished through the occlusion of the anterior descending branch of the left coronary artery. We found that compared with the model groups, CCSTM decreased the infarct size in models of CI and MI in a dose-dependent manner. After brain ischemia, CCSTM decreased the level of myeloperoxidase (MPO) and malondialdehyde (MDA), and increased the level of superoxide dismutase (SOD). Besides, CCSTM reduced the concentrations of lactate dehydrogenase (LDH), malondialdehyde MDA, and endothelin (ET) in the plasma of rats injured with MI. Histological examination of brain sections revealed that CCSTM alleviated cerebral damage after ischemia compared with the model group. CCSTM can reduce myocardial and cerebral infarction injury, and the oxidation level after myocardial and cerebral infarction in rats.
