The Local Atomic Structure of Colloidal Superparamagnetic Iron Oxide Nanoparticles for Theranostics in Oncology

Abstract

The paper contains an overview of modern spectroscopic methods for studying the local atomic structure of superparamagnetic nanoparticles based on iron oxide (SPIONs), which are an important class of materials promising for theranostics in oncology. Practically important properties of small and ultra small nanoparticles are determined primarily by their shape, size, and features of the local atomic, electronic, and magnetic structures, for the study of which the standard characterization methods developed for macroscopic materials are not optimal. The paper analyzes results of the studies of SPIONs local atomic structure carried out by X-ray absorption spectroscopy at synchrotron radiation sources and Mössbauer spectroscopy during the last decade.

Keywords

• superparamagnetic iron oxide nanoparticles (SPION), theranostics in oncology
• local atomic structure
• XANES spectroscopy
• Mössbauer spectroscopy