Adult form of Langerhans cell histiocytosis with pulmonary and hepatic involvement mimicking malignancy in a patient with chronic hepatitis C infection

Barbara Moullet, MD; Mirjam Kolev, MD; Lukas Ebner, MD; Rupert Langer, MD; Christoph Gräni, MD, PhD; Verena Obmann, MD; Martin Maurer, MD; Nasser Semmo, MD, PhD; Andreas Christe, MD; Adrian Thomas Huber, MD, PhD

Radiology Case Reports (Feb 2021)

Adult form of Langerhans cell histiocytosis with pulmonary and hepatic involvement mimicking malignancy in a patient with chronic hepatitis C infection

Barbara Moullet, MD,
Mirjam Kolev, MD,
Lukas Ebner, MD,
Rupert Langer, MD,
Christoph Gräni, MD, PhD,
Verena Obmann, MD,
Martin Maurer, MD,
Nasser Semmo, MD, PhD,
Andreas Christe, MD,
Adrian Thomas Huber, MD, PhD

Affiliations

Barbara Moullet, MD: Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital, University of Bern, Freiburgstrasse 10, Inselspital, 3010, Bern, Switzerland
Mirjam Kolev, MD: Hepatology, Department of Visceral Surgery and Medicine, Inselspital University Hospital, University of Bern, Bern, Switzerland
Lukas Ebner, MD: Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital, University of Bern, Freiburgstrasse 10, Inselspital, 3010, Bern, Switzerland
Rupert Langer, MD: Department of Pathology, Inselspital University Hospital, University of Bern, Bern, Switzerland
Christoph Gräni, MD, PhD: Department of Cardiology, Inselspital University Hospital, University of Bern, Bern, Switzerland
Verena Obmann, MD: Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital, University of Bern, Freiburgstrasse 10, Inselspital, 3010, Bern, Switzerland
Martin Maurer, MD: Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital, University of Bern, Freiburgstrasse 10, Inselspital, 3010, Bern, Switzerland
Nasser Semmo, MD, PhD: Hepatology, Department of Visceral Surgery and Medicine, Inselspital University Hospital, University of Bern, Bern, Switzerland
Andreas Christe, MD: Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital, University of Bern, Freiburgstrasse 10, Inselspital, 3010, Bern, Switzerland
Adrian Thomas Huber, MD, PhD: Department of Diagnostic, Interventional and Pediatric Radiology, Inselspital University Hospital, University of Bern, Freiburgstrasse 10, Inselspital, 3010, Bern, Switzerland; Corresponding author.

Journal volume & issue: Vol. 16, no. 2
pp. 327 – 333

Abstract

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Langerhans cell histiocytosis (LCH) is a myeloid neoplasm with inflammatory properties. There are few published reports of adult LCH with liver involvement, which is still poorly understood, but shows high morbidity and mortality. We report a case of a 37-year-old woman suffering from hepatitis C showing a LCH affecting the lung as well as the liver. Consistent with histology, we found an early stage of a proliferative/granulomatous phase of hepatobiliary LCH, whereas pulmonary findings showed a nodular stage of adult pulmonary LCH. Although hepatocellular carcinoma is a common malignancy in patients suffering from hepatitis C, it is crucial to keep in mind differential diagnosis for newly appearing liver lesions.

Published in Radiology Case Reports

ISSN: 1930-0433 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Medicine (General): Medical physics. Medical radiology. Nuclear medicine
Website: https://www.sciencedirect.com/journal/radiology-case-reports

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