mBio
(Jun 2021)
Analysis of the Oxidative Stress Regulon Identifies
<i>soxS</i>
as a Genetic Target for Resistance Reversal in Multidrug-Resistant Klebsiella pneumoniae
João Anes,
Katherine Dever,
Athmanya Eshwar,
Scott Nguyen,
Yu Cao,
Sathesh K. Sivasankaran,
Sandra Sakalauskaitė,
Angelika Lehner,
Stéphanie Devineau,
Rimantas Daugelavičius,
Roger Stephan,
Séamus Fanning,
Shabarinath Srikumar
Affiliations
João Anes
ORCiD UCD-Centre for Food Safety, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland
Katherine Dever
ORCiD UCD-Centre for Food Safety, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland
Athmanya Eshwar
ORCiD Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland
Scott Nguyen
ORCiD UCD-Centre for Food Safety, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland
Yu Cao
ORCiD UCD-Centre for Food Safety, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland
Sathesh K. Sivasankaran
ORCiD Genome Informatics Facility, Iowa State University, Ames, Iowa, USA
Sandra Sakalauskaitė
ORCiD Department of Biochemistry, Faculty of Natural Sciences, Vytautas Magnus University, Kaunas, Lithuania
Angelika Lehner
ORCiD Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland
Stéphanie Devineau
ORCiD Université de Paris, BFA, UMR 8251, CNRS, Paris, France
Rimantas Daugelavičius
ORCiD Department of Biochemistry, Faculty of Natural Sciences, Vytautas Magnus University, Kaunas, Lithuania
Roger Stephan
ORCiD Institute for Food Safety and Hygiene, University of Zurich, Zurich, Switzerland
Séamus Fanning
ORCiD UCD-Centre for Food Safety, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland
Shabarinath Srikumar
ORCiD UCD-Centre for Food Safety, UCD School of Public Health, Physiotherapy and Sports Science, University College Dublin, Dublin, Ireland
DOI
https://doi.org/10.1128/mBio.00867-21
Journal volume & issue
Vol. 12,
no. 3
Abstract
Read online
Antimicrobial resistance is a global health challenge. Few new antibiotics have been developed for use over the years, and preserving the efficacy of existing compounds is an important step to protect public health. This paper describes a study that examines the effects of exogenously induced oxidative stress on K. pneumoniae
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