Vascular Risk Factors and Clinical Progression in Spinocerebellar Ataxias

Raymond Y. Lo; Karla P. Figueroa; Stefan M. Pulst; Chi-Ying Lin; Susan Perlman; George Wilmot; Christopher M. Gomez; Jeremy Schmahmann; Henry Paulson; Vikram G. Shakkottai; Sarah H. Ying; Theresa Zesiewicz; Khalaf Bushara; Michael Geschwind; Guangbin Xia; S S. Subramony; Tetsuo Ashizawa; Sheng-Han Kuo

doi:10.7916/D89885S0

Tremor and Other Hyperkinetic Movements (Feb 2015)

Vascular Risk Factors and Clinical Progression in Spinocerebellar Ataxias

Raymond Y. Lo,
Karla P. Figueroa,
Stefan M. Pulst,
Chi-Ying Lin,
Susan Perlman,
George Wilmot,
Christopher M. Gomez,
Jeremy Schmahmann,
Henry Paulson,
Vikram G. Shakkottai,
Sarah H. Ying,
Theresa Zesiewicz,
Khalaf Bushara,
Michael Geschwind,
Guangbin Xia,
S S. Subramony,
Tetsuo Ashizawa,
Sheng-Han Kuo

Affiliations

Raymond Y. Lo: Department of Neurology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
Karla P. Figueroa: Department of Neurology, University of Utah, Salt Lake City, UT, USA
Stefan M. Pulst: Department of Neurology, University of Utah, Salt Lake City, UT, USA
Chi-Ying Lin: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA
Susan Perlman: Department of Neurology, University of California, Los Angeles, CA, USA
George Wilmot: Department of Neurology, Emory University, Atlanta, GA, USA
Christopher M. Gomez: Department of Neurology, University of Chicago, Chicago, IL, USA
Jeremy Schmahmann: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Henry Paulson: Department of Neurology, University of Michigan, Ann Arbor, MI, USA
Vikram G. Shakkottai: Department of Neurology, University of Michigan, Ann Arbor, MI, USA
Sarah H. Ying: Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Theresa Zesiewicz: Department of Neurology, University of South Florida, Tampa, FL, USA
Khalaf Bushara: Department of Neurology, University of Minnesota, Minneapolis, MN, USA
Michael Geschwind: Department of Neurology, University of California, San Francisco, CA, USA
Guangbin Xia: Department of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, USA
S S. Subramony: Department of Neurology and McKnight Brain Institute, University of Florida, Gainesville, FL, USA
Tetsuo Ashizawa: S. H.
Sheng-Han Kuo: Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA

DOI: https://doi.org/10.7916/D89885S0
Journal volume & issue: Vol. 5

Abstract

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Background: The contributions of vascular risk factors to spinocerebellar ataxia (SCA) are not known.Methods: We studied 319 participants with SCA 1, 2, 3, and 6 and repeatedly measured clinical severity using the Scale for Assessment and Rating of Ataxia (SARA) for 2 years. Vascular risk factors were summarized by CHA2DS2-VASc scores as the vascular risk factor index. We employed regression models to study the effects of vascular risk factors on ataxia onset and progression after adjusting for age, sex, and pathological CAG repeats. Our secondary analyses took hyperlipidemia into account.Results: Nearly 60% of SCA participants were at low vascular risks with CHA2DS2-VASc = 0, and 31% scored 2 or greater. Higher CHA2DS2-VASc scores were not associated with either earlier onset or faster progression of ataxia. These findings were not altered after accounting for hyperlipidemia. Discussion: Vascular risks are not common in SCAs and are not associated with earlier onset or faster ataxia progression.

Published in Tremor and Other Hyperkinetic Movements

ISSN: 2160-8288 (Online)
Publisher: Ubiquity Press
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the musculoskeletal system; Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry: Neurology. Diseases of the nervous system
Website: https://tremorjournal.org

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