Nature Communications (Sep 2024)
Regional patterns of human cortex development correlate with underlying neurobiology
- Leon D. Lotter,
- Amin Saberi,
- Justine Y. Hansen,
- Bratislav Misic,
- Casey Paquola,
- Gareth J. Barker,
- Arun L. W. Bokde,
- Sylvane Desrivières,
- Herta Flor,
- Antoine Grigis,
- Hugh Garavan,
- Penny Gowland,
- Andreas Heinz,
- Rüdiger Brühl,
- Jean-Luc Martinot,
- Marie-Laure Paillère,
- Eric Artiges,
- Dimitri Papadopoulos Orfanos,
- Tomáš Paus,
- Luise Poustka,
- Sarah Hohmann,
- Juliane H. Fröhner,
- Michael N. Smolka,
- Nilakshi Vaidya,
- Henrik Walter,
- Robert Whelan,
- Gunter Schumann,
- IMAGEN Consortium,
- Frauke Nees,
- Tobias Banaschewski,
- Simon B. Eickhoff,
- Juergen Dukart
Affiliations
- Leon D. Lotter
- Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich
- Amin Saberi
- Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich
- Justine Y. Hansen
- McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University
- Bratislav Misic
- McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University
- Casey Paquola
- Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich
- Gareth J. Barker
- Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King’s College London
- Arun L. W. Bokde
- Discipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, Trinity College Dublin
- Sylvane Desrivières
- Centre for Population Neuroscience and Precision Medicine (PONS), Institute of Psychiatry, Psychology & Neuroscience, SGDP Centre, King’s College London
- Herta Flor
- Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Antoine Grigis
- NeuroSpin, CEA, Université Paris-Saclay
- Hugh Garavan
- Departments of Psychiatry and Psychology, University of Vermont
- Penny Gowland
- Sir Peter Mansfield Imaging Centre School of Physics and Astronomy, University of Nottingham; University Park
- Andreas Heinz
- Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Rüdiger Brühl
- Physikalisch-Technische Bundesanstalt (PTB); Braunschweig and Berlin
- Jean-Luc Martinot
- Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Université paris Cité, INSERM U1299 “Trajectoires Développementales & Psychiatrie”; Centre Borelli
- Marie-Laure Paillère
- Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Université paris Cité, INSERM U1299 “Trajectoires Développementales & Psychiatrie”; Centre Borelli
- Eric Artiges
- Ecole Normale Supérieure Paris-Saclay, Université Paris-Saclay, Université paris Cité, INSERM U1299 “Trajectoires Développementales & Psychiatrie”; Centre Borelli
- Dimitri Papadopoulos Orfanos
- NeuroSpin, CEA, Université Paris-Saclay
- Tomáš Paus
- Departments of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal
- Luise Poustka
- Department of Child and Adolescent Psychiatry and Psychotherapy, University Medical Centre Göttingen
- Sarah Hohmann
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Juliane H. Fröhner
- Department of Psychiatry and Psychotherapy, Technische Universität Dresden
- Michael N. Smolka
- Department of Psychiatry and Psychotherapy, Technische Universität Dresden
- Nilakshi Vaidya
- Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin
- Henrik Walter
- Department of Psychiatry and Psychotherapy CCM, Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
- Robert Whelan
- School of Psychology and Global Brain Health Institute, Trinity College Dublin
- Gunter Schumann
- Centre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Neuroscience, Charité Universitätsmedizin Berlin
- IMAGEN Consortium
- Frauke Nees
- Institute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Tobias Banaschewski
- Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University
- Simon B. Eickhoff
- Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich
- Juergen Dukart
- Institute of Neuroscience and Medicine, Brain & Behaviour (INM-7), Research Centre Jülich
- DOI
- https://doi.org/10.1038/s41467-024-52366-7
- Journal volume & issue
-
Vol. 15,
no. 1
pp. 1 – 21
Abstract
Abstract Human brain morphology undergoes complex changes over the lifespan. Despite recent progress in tracking brain development via normative models, current knowledge of underlying biological mechanisms is highly limited. We demonstrate that human cortical thickness development and aging trajectories unfold along patterns of molecular and cellular brain organization, traceable from population-level to individual developmental trajectories. During childhood and adolescence, cortex-wide spatial distributions of dopaminergic receptors, inhibitory neurons, glial cell populations, and brain-metabolic features explain up to 50% of the variance associated with a lifespan model of regional cortical thickness trajectories. In contrast, modeled cortical thickness change patterns during adulthood are best explained by cholinergic and glutamatergic neurotransmitter receptor and transporter distributions. These relationships are supported by developmental gene expression trajectories and translate to individual longitudinal data from over 8000 adolescents, explaining up to 59% of developmental change at cohort- and 18% at single-subject level. Integrating neurobiological brain atlases with normative modeling and population neuroimaging provides a biologically meaningful path to understand brain development and aging in living humans.
