Data on trajectories of measures of cardiovascular health in the Avon Longitudinal Study of Parents and Children (ALSPAC)
Linda M. O’Keeffe,
Andrew J. Simpkin,
Kate Tilling,
Emma L. Anderson,
Alun D. Hughes,
Debbie A. Lawlor,
Abigail Fraser,
Laura D. Howe
Affiliations
Linda M. O’Keeffe
MRC Integrative Epidemiology Unit at the University of Bristol, UK; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Ireland, UK; Corresponding author.
Andrew J. Simpkin
MRC Integrative Epidemiology Unit at the University of Bristol, UK; Population Health Sciences, Bristol Medical School, University of Bristol, UK; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Ireland, UK
Kate Tilling
MRC Integrative Epidemiology Unit at the University of Bristol, UK; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Ireland, UK
Emma L. Anderson
MRC Integrative Epidemiology Unit at the University of Bristol, UK; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Ireland, UK
Alun D. Hughes
Department of Population Science & Experimental Medicine, Institute of Cardiovascular Science, University College London, UK; MRC Unit for Lifelong Health and Ageing at University College London, London, UK
Debbie A. Lawlor
MRC Integrative Epidemiology Unit at the University of Bristol, UK; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Ireland, UK
Abigail Fraser
MRC Integrative Epidemiology Unit at the University of Bristol, UK; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Ireland, UK
Laura D. Howe
MRC Integrative Epidemiology Unit at the University of Bristol, UK; School of Mathematics, Statistics and Applied Mathematics, National University of Ireland, Galway, Ireland, UK
Cardiometabolic disease risk begins in early life and tracks through the life course. As described in “Sex-specific trajectories of measures of cardiovascular health during childhood and adolescence: a prospective cohort study” (O’Keeffe et al., 2018), we modelled sex-specific change in 11 key measures of cardiovascular health from birth/early childhood to age 18 years in a British birth cohort study, the Avon Longitudinal Study of Parents and Children (ALSPAC). In this article, we describe the data used in these analyses. Risk factors measured included BMI, fat and lean mass, blood pressure and blood-based biomarkers. Data are from several sources including cord blood at birth, clinic assessments, routine health records, questionnaires and nuclear magnetic resonance spectroscopy. Outcomes were measured over varying time spans from birth or mid-childhood to age 18 and with different numbers of repeated measures per outcome. Analyses were performed using fractional polynomial and linear spline multilevel models. Further information can be found in O’Keeffe et al. (2018).
