The tert-Amino Effect in Heterocyclic Chemistry. Synthesis of Spiro Heterocycles

Abstract

The tert-amino reaction effect was examined. A new method to synthesize spiro heterocycles is presented. It was shown that the “tert-amino effect” could be applied to the formation of spiro-fused heterocycles. The formation of spiro compounds proceeds in most cases in good yields in a one-pot reaction.

Keywords

• Tert-amino effect
• cyclization
• spiro compounds
• Knoevenagel condensation
• 1
• 2
• 3-thiadiazole
• pyrazole
• quinoline