Nature Communications (Apr 2017)
IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population
Abstract
Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-33-induced ILC2 activation of IL-10 production by macrophages.