Nature Communications (Apr 2017)

IL-33 contributes to sepsis-induced long-term immunosuppression by expanding the regulatory T cell population

  • Daniele C. Nascimento,
  • Paulo H. Melo,
  • Annie R. Piñeros,
  • Raphael G. Ferreira,
  • David F. Colón,
  • Paula B. Donate,
  • Fernanda V. Castanheira,
  • Aline Gozzi,
  • Paula G. Czaikoski,
  • Wanda Niedbala,
  • Marcos C. Borges,
  • Dario S. Zamboni,
  • Foo Y. Liew,
  • Fernando Q. Cunha,
  • Jose C. Alves-Filho

DOI
https://doi.org/10.1038/ncomms14919
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 14

Abstract

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Patients who survive sepsis are at increased risk of infection owing to long-term immunosuppression that is associated with an increase in Treg cell numbers. Here the authors show expansion of the Treg cell population in sepsis mice is driven by IL-33-induced ILC2 activation of IL-10 production by macrophages.