Hypertension in Pregnancy (Oct 2020)

Tumor necrosis factor alpha (TNF-α) blockade improves natural killer cell (NK) activation, hypertension, and mitochondrial oxidative stress in a preclinical rat model of preeclampsia

  • Mark W. Cunningham,
  • Aswathi Jayaram,
  • Evangeline Deer,
  • Lorena M. Amaral,
  • Venkata Ramana Vaka,
  • Tarek Ibrahim,
  • Denise C. Cornelius,
  • Babbette LaMarca

DOI
https://doi.org/10.1080/10641955.2020.1793999
Journal volume & issue
Vol. 39, no. 4
pp. 399 – 404

Abstract

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The RUPP rat model of Preeclampsia exhibits hypertension (MAP), cytolytic natural killer (cNK) cells, tumor necrosis factor alpha (TNF-α) and mitochondrial Reactive Oxygen Species (mt ROS). Objective: Does TNF-α blockade with ETAN (Etanercept) decrease cNK cell and mt ROS in RUPP rats. Methods: On gestational day 14, RUPP surgery was performed, ETAN (0.4 mg/kg) was administered on day 18, MAP, blood and tissues collected on 19. Results:MAP, cytolytic NK cells and mt ROS were elevated in RUPP vs. NP and normalized with ETAN. Conclusion: TNF-α blockade lowered blood pressure and improve inflammation and organ function in response to placental ischemia.

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