Thrombin-activated platelet-rich plasma enhances osteogenic differentiation of human periodontal ligament stem cells by activating SIRT1-mediated autophagy

Abstract

Highlights 1. PRP enhances cell viability and osteogenic differentiation of hPDLSCs. 2. Activated PRP dose-dependently increases cell autophagy. 3. Inhibition of autophagy abrogates PRP-induced osteogenic differentiation of hPDLSCs.

Keywords

• Autophagy
• Osteogenic differentiation
• Periodontal ligament stem cells
• Platelet-rich plasma
• Viability