Emerging peptide antibiotics with therapeutic potential

Abstract

This review covers some of the recent progress in the field of peptide antibiotics with a focus on compounds with novel or established mode of action and with demonstrated efficacy in animal infection models. Novel drug discovery approaches, linear and macrocyclic peptide antibiotics, lipopeptides like the polymyxins as well as peptides addressing targets located in the plasma membrane or in the outer membrane of bacterial cells are discussed.

Keywords

• Antibiotic
• antimicrobial peptide
• antimicrobial resistance
• OMPTA (outer membrane targeting antibiotic)
• peptide antibiotic
• lipopeptide