Data in Brief
(Feb 2017)
Data showing proliferation and differentiation of intestinal epithelial cells under targeted depletion of Notch ligands in mouse intestine
Toru Nakata,
Hiromichi Shimizu,
Sayaka Nagata,
Go Ito,
Satoru Fujii,
Kohei Suzuki,
Ami Kawamoto,
Fumiaki Ishibashi,
Reiko Kuno,
Sho Anzai,
Tatsuro Murano,
Tomohiro Mizutani,
Shigeru Oshima,
Kiichiro Tsuchiya,
Tetsuya Nakamura,
Katsuto Hozumi,
Mamoru Watanabe,
Ryuichi Okamoto
Affiliations
Toru Nakata
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Hiromichi Shimizu
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Sayaka Nagata
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Go Ito
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Satoru Fujii
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Kohei Suzuki
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Ami Kawamoto
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Fumiaki Ishibashi
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Reiko Kuno
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Sho Anzai
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Tatsuro Murano
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Tomohiro Mizutani
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Shigeru Oshima
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Kiichiro Tsuchiya
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Tetsuya Nakamura
Department of Advanced Therapeutics in GI Diseases, Tokyo Medical and Dental University, Tokyo, Japan
Katsuto Hozumi
Department of Immunology, Tokai University School of Medicine, Isehara, Japan
Mamoru Watanabe
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
Ryuichi Okamoto
Department of Gastroenterology and Hepatology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
DOI
https://doi.org/10.1016/j.dib.2016.12.045
Journal volume & issue
Vol. 10,
no. C
Abstract
Read online
The data on the immunohistochemical analysis of conditional Notch ligand knockout mice is presented. Targeted deletion of Jag1, Dll1, Dll4, or Dll1 plus Dll4 in Lgr5+ve cells was induced by a Cre-mediated gene recombination, and differentiation or proliferation of the intestinal epithelial cells was examined by immunohistochemistry. These data are the extension of the data presented and discussed in the paper entitled “Indispensable role of non-canonical Notch signaling in the proliferation of Apc-deficient intestinal tumors“ (Nakata et al., Submitted for publication) [1].
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