Fetal origin of bronchopulmonary dysplasia: contribution of intrauterine inflammation

Abstract

Abstract Bronchopulmonary dysplasia (BPD) is a common chronic lung disease in infants and the most frequent adverse outcome of premature birth, despite major efforts to minimize injury. It is thought to result from aberrant repair response triggered by either prenatal or recurrent postnatal injury to the lungs during development. Intrauterine inflammation is an important risk factor for prenatal lung injury, which is also increasingly linked to BPD. However, the specific mechanisms remain unclear. This review summarizes clinical and animal research linking intrauterine inflammation to BPD. We assess how intrauterine inflammation affects lung alveolarization and vascular development. In addition, we discuss prenatal therapeutic strategies targeting intrauterine inflammation to prevent or treat BPD.

Keywords

• Bronchopulmonary dysplasia
• Intrauterine inflammation
• Fetal inflammatory response
• Chorioamnionitis
• Alveolarization
• Vascular development