Frontiers in Oncology (Oct 2020)

Stage III Esophageal Squamous Cell Carcinoma Patients With Three-Dimensional Conformal or Intensity-Modulated Radiotherapy: A Multicenter Retrospective Study

  • Qin Qin,
  • Xiaolin Ge,
  • Xin Wang,
  • Lan Wang,
  • Chen Li,
  • Junqiang Chen,
  • Xiaomin Wang,
  • Yidian Zhao,
  • Wencheng Zhang,
  • Ping Wang,
  • Qingsong Pang,
  • Kaixian Zhang,
  • Ling Li,
  • Miaomiao Hu,
  • Chongli Hao,
  • Gaofeng Li,
  • Yonggang Xu,
  • Xueying Qiao,
  • Zhiguo Zhou,
  • Shuchai Zhu,
  • Wenbin Shen,
  • Yati Wang,
  • Na Lu,
  • Miaoling Liu,
  • Shuai Qie,
  • Chun Han,
  • Zefen Xiao,
  • Xinchen Sun

DOI
https://doi.org/10.3389/fonc.2020.580450
Journal volume & issue
Vol. 10

Abstract

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Aim: To evaluate long-term outcome and prognostic factors of stage III esophageal cancer after definitive radiotherapy using three dimensional conformal radiotherapy (3DCRT) or intensity-modulated radiotherapy (IMRT) techniques.Methods: Patients with T3N1M0/T4N0-1M0 esophageal squamous cell carcinoma (ESCC) treated with definitive radiotherapy from 2002 to 2016 in 10 Chinese medical centers were retrospectively analyzed. Overall survival (OS) and progression-free survival (PFS) rates were calculated. Prognostic factors were analyzed by Log-rank test and multivariable Cox model.Results: Survival data of 1,450 patients were retrospectively collected. With a median follow-up time of 65.9 months, 1-, 3-, and 5-year OS rates were 69.3, 36.7, and 27.7%, respectively, and PFS rates were 58.6, 32.7, and 27.4%, respectively. Univariable analyses showed that gender, age, lesion location, lesion length, largest tumor diameter, lymph node metastasis, gross tumor volume, EQD2, short-term response, and concurrent chemotherapy were prognostic factors for OS. Multivariable analyses showed that lesion location, T-classification, GTV size, EQD2, and short-term response to RT were independent prognostic factors for OS, and tumor diameter, GTV size, and short-term response were independent prognostic factors for PFS.Conclusions: This study demonstrated that definitive radiotherapy using 3DCRT and IMRT provides promising outcomes for locally advanced ESCC.

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