STUDY THE ROLE OF TITANIUM DIOXIDE (TIO2) NANOPARTICLES AGAINST THE TOXICITY OF Echinococcus granulosus IN ADULT ALBINO MALE RATS

Abstract

The present study was designed to show the role of green Tio2 nanoparticles against toxicityof Echinococcus granulosus. The present study used 16 adult albino male rats that distributedrandomly to following groups (each group consist 5 rats); control group received ad libidium,second group injected with 2,5 X 103 of Echinococcus granulosus protoscolices third groupinjected with protoscolices and treated with 50mg/kg green Tio2 nanoparticles, fourth groupinjected with protoscolices and treated with 100mg/kg green Tio2 nanoparticles. The resultsshow high significant increased (P < 0.05) in levels of Alanine Aminotransferase (ALT),Aspartate Aminotransferase (AST), Alkaline Phosphatase (ALP) in group injected withprotoscolices compared with control group. Oxidative stress factor in group injected withprotoscolices show significant increased (P < 0.05) in levels of MDA (malonedialdehyied) andsignificant decreased (P < 0.05) in levels of glutathione (GSH) and catalase compared withcontrol group. While, after used green Tio2 nanoparticles with Echinococcus granulosus, theresults showed non-significant changes (P < 0.05) in liver functions and MDA, GSH and catalasealso showed non-significant changes (P < 0.05) compared with control group. It was concludedthat green Tio2 nanoparticles has been potential role against toxicity of Echinococcus granulosusin male rats.

Keywords

• tio2 nanoparticles
• mda (malonedialdehyied)
• glutathione (gsh)