Zaporožskij Medicinskij Žurnal (Jun 2015)

The level of plasma homocysteine in patients with non-alcoholic fatty liver disease in combination with type 2 diabetes

  • V. F. Orlovskiy ,
  • N. G. Kuchma,
  • A. V. Orlovskiy,
  • N. O. Murenets

DOI
https://doi.org/10.14739/2310-1210.2015.3.44489
Journal volume & issue
no. 3
pp. 65 – 68

Abstract

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Non-alcoholic fatty liver disease (NAFLD) is one of the major causes of chronic diseases of the hepatobiliary zone. Aim. In order to explore new pathogenetic factors of NAFLD examined the level of plasma homocysteine in 110 patients. Methods and results. Patients were divided into two groups - the isolated NAFLD and in combination with Diabetes mellitus type 2. Found a significant increase in homocysteine level in all patients with NAFLD compared with the control group. High homocysteine concentration was in patients with comorbidity. There was positive correlation between levels of homocysteine and lipid components and cytolytic syndrome in all patients. Conclusion. The data obtained allow us to consider homocysteine as one of the factors in the pathological changes development in the liver.

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