TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

Nicole Maloney Belle; Yingbiao Ji; Karl Herbine; Yun Wei; JoonHyung Park; Kelly Zullo; Li-Yin Hung; Sriram Srivatsa; Tanner Young; Taylor Oniskey; Christopher Pastore; Wildaliz Nieves; Ma Somsouk; De’Broski R. Herbert

doi:10.1038/s41467-019-12315-1

Nature Communications (Sep 2019)

TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths

Nicole Maloney Belle,
Yingbiao Ji,
Karl Herbine,
Yun Wei,
JoonHyung Park,
Kelly Zullo,
Li-Yin Hung,
Sriram Srivatsa,
Tanner Young,
Taylor Oniskey,
Christopher Pastore,
Wildaliz Nieves,
Ma Somsouk,
De’Broski R. Herbert

Affiliations

Nicole Maloney Belle: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Yingbiao Ji: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Karl Herbine: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Yun Wei: Division of Experimental Medicine, University of California, San Francisco
JoonHyung Park: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Kelly Zullo: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Li-Yin Hung: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Sriram Srivatsa: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Tanner Young: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Taylor Oniskey: Division of Experimental Medicine, University of California, San Francisco
Christopher Pastore: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine
Wildaliz Nieves: Division of Gastroenterology at ZSFG, University of California, San Francisco
Ma Somsouk: Division of Gastroenterology at ZSFG, University of California, San Francisco
De’Broski R. Herbert: Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine

DOI: https://doi.org/10.1038/s41467-019-12315-1
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 13

Abstract

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TFF3 secretion by goblet cells regulates mucus viscosity and wound healing, but a receptor for TFF3 has not been identified. Here, the authors show that TFF3 binds LINGO2 to de-repress and enhance EGFR signaling that drives wound healing and immunity against helminths.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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