Neutrophils/Lymphocytes and MPV/PC index assessed in stroke during elderly, is there a difference?

Abstract

Introduction: In stroke the inflammatory response depends on the neutrophils and leukocytes, reason why the neutrophil/lymphocyte (N/L) and mean platelet volume/platelet count (MPV/PC) indexes are considered to assess stroke. Aim: We aim to determine which index, N/L index or mean platelet volume/platelet count, is better to assess stroke in elderly. Methods: We retrospectively review files of patients over 65 years old with the previous stroke during the period of 2019-2022, including 180 patients (72 males 69-78 years and 108 females 67-84 years). All patients had brain imaging, initial and followup hematic cytometry to determine indexes and compare it between them. Results: Most patients had N/L 0.031 (p = 0.0021) during the first 48 h. The receiver operating characteristic showed area under the curve (AUC) values of MPV/PC = 0.872 (0.816-0.929) (p = 0.001) and N/L = 0.647 (0.564-0.730) (p = 0.001) with a significant difference between AUC values (p = 0.001). Conclusions: Mortality rises in 76-80 years group; males had a higher mortality in ischemic events compared to females. The MPV/PC is better to predict severe events and long hospital stay, which could be used as a prognosis during the first 48 h of hospitalization.

Keywords

• Mean platelet volume. Neutrophils/lymphocytes. Stroke. Mortality