Nature Communications (Oct 2022)
Integrative analysis of KRAS wildtype metastatic pancreatic ductal adenocarcinoma reveals mutation and expression-based similarities to cholangiocarcinoma
- James T. Topham,
- Erica S. Tsang,
- Joanna M. Karasinska,
- Andrew Metcalfe,
- Hassan Ali,
- Steve E. Kalloger,
- Veronika Csizmok,
- Laura M. Williamson,
- Emma Titmuss,
- Karina Nielsen,
- Gian Luca Negri,
- Sandra E. Spencer Miko,
- Gun Ho Jang,
- Robert E. Denroche,
- Hui-li Wong,
- Grainne M. O’Kane,
- Richard A. Moore,
- Andrew J. Mungall,
- Jonathan M. Loree,
- Faiyaz Notta,
- Julie M. Wilson,
- Oliver F. Bathe,
- Patricia A. Tang,
- Rachel Goodwin,
- Gregg B. Morin,
- Jennifer J. Knox,
- Steven Gallinger,
- Janessa Laskin,
- Marco A. Marra,
- Steven J. M. Jones,
- David F. Schaeffer,
- Daniel J. Renouf
Affiliations
- James T. Topham
- Pancreas Centre BC
- Erica S. Tsang
- Division of Medical Oncology, BC Cancer
- Joanna M. Karasinska
- Pancreas Centre BC
- Andrew Metcalfe
- Pancreas Centre BC
- Hassan Ali
- Pancreas Centre BC
- Steve E. Kalloger
- Pancreas Centre BC
- Veronika Csizmok
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Laura M. Williamson
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Emma Titmuss
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Karina Nielsen
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Gian Luca Negri
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Sandra E. Spencer Miko
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Gun Ho Jang
- Ontario Institute for Cancer Research
- Robert E. Denroche
- Ontario Institute for Cancer Research
- Hui-li Wong
- Division of Medical Oncology, BC Cancer
- Grainne M. O’Kane
- Ontario Institute for Cancer Research
- Richard A. Moore
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Andrew J. Mungall
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Jonathan M. Loree
- Division of Medical Oncology, BC Cancer
- Faiyaz Notta
- Ontario Institute for Cancer Research
- Julie M. Wilson
- Ontario Institute for Cancer Research
- Oliver F. Bathe
- Departments of Surgery and Oncology, Cummings School of Medicine, University of Calgary
- Patricia A. Tang
- Departments of Surgery and Oncology, Cummings School of Medicine, University of Calgary
- Rachel Goodwin
- The Ottawa Hospital Cancer Centre, Ottawa Hospital Research Institute
- Gregg B. Morin
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Jennifer J. Knox
- University Health Network, University of Toronto
- Steven Gallinger
- Ontario Institute for Cancer Research
- Janessa Laskin
- Division of Medical Oncology, BC Cancer
- Marco A. Marra
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- Steven J. M. Jones
- Canada’s Michael Smith Genome Sciences Centre, BC Cancer
- David F. Schaeffer
- Pancreas Centre BC
- Daniel J. Renouf
- Pancreas Centre BC
- DOI
- https://doi.org/10.1038/s41467-022-33718-7
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
KRAS wildtype metastatic pancreatic ductal adenocarcinoma (mPDAC) could represent a distinct molecular entity from other PDACs. Here, the authors analyse KRAS wildtype mPDAC tumours using genomics and transcriptomics and find molecular similarities with cholangiocarcinomas.
