Antimicrobial Metabolites against Methicillin-Resistant <i>Staphylococcus aureus</i> from the Endophytic Fungus <i>Neofusicoccum australe</i>

Abstract

Antimicrobial bioassay-guided fractionation of the endophytic fungi Neofusicoccum australe led to the isolation of a new unsymmetrical naphthoquinone dimer, neofusnaphthoquinone B (1), along with four known natural products (2–5). Structure elucidation was conducted by nuclear magnetic resonance (NMR) spectroscopic methods, and the antimicrobial activity of all the natural products was investigated, revealing 1 to be moderately active towards methicillin-resistant Staphylococcus aureus (MRSA) with a minimum inhibitory concentration (MIC) of 16 µg/mL.

Keywords

• antimicrobial
• natural product
• fungi
• MRSA
• naphthoquinone dimer