Nature Communications (Jun 2020)
Post-surgical adhesions are triggered by calcium-dependent membrane bridges between mesothelial surfaces
- Adrian Fischer,
- Tim Koopmans,
- Pushkar Ramesh,
- Simon Christ,
- Maximilian Strunz,
- Juliane Wannemacher,
- Michaela Aichler,
- Annette Feuchtinger,
- Axel Walch,
- Meshal Ansari,
- Fabian J. Theis,
- Kenji Schorpp,
- Kamyar Hadian,
- Philipp-Alexander Neumann,
- Herbert B. Schiller,
- Yuval Rinkevich
Affiliations
- Adrian Fischer
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Regenerative Biology and Medicine, Member of the German Center for Lung Research (DZL)
- Tim Koopmans
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Regenerative Biology and Medicine, Member of the German Center for Lung Research (DZL)
- Pushkar Ramesh
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Regenerative Biology and Medicine, Member of the German Center for Lung Research (DZL)
- Simon Christ
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Regenerative Biology and Medicine, Member of the German Center for Lung Research (DZL)
- Maximilian Strunz
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Systems Medicine of Chronic Lung Disease, Member of the German Center for Lung Research (DZL)
- Juliane Wannemacher
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Regenerative Biology and Medicine, Member of the German Center for Lung Research (DZL)
- Michaela Aichler
- Research Unit of Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München
- Annette Feuchtinger
- Research Unit of Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München
- Axel Walch
- Research Unit of Analytical Pathology, German Research Center for Environmental Health, Helmholtz Zentrum München
- Meshal Ansari
- Helmholtz Zentrum München, Institute of Computational Biology
- Fabian J. Theis
- Helmholtz Zentrum München, Institute of Computational Biology
- Kenji Schorpp
- Helmholtz Zentrum München, Assay Development and Screening Platform, Institute for Molecular Toxicology and Pharmacology
- Kamyar Hadian
- Helmholtz Zentrum München, Assay Development and Screening Platform, Institute for Molecular Toxicology and Pharmacology
- Philipp-Alexander Neumann
- Technical University of Munich, School of Medicine, Klinikum rechts der Isar, Department of Surgery
- Herbert B. Schiller
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Systems Medicine of Chronic Lung Disease, Member of the German Center for Lung Research (DZL)
- Yuval Rinkevich
- Helmholtz Zentrum München, Institute of Lung Biology and Disease, Regenerative Biology and Medicine, Member of the German Center for Lung Research (DZL)
- DOI
- https://doi.org/10.1038/s41467-020-16893-3
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Surgical adhesions are organ-joining bands of scar tissue that remain clinically untreatable. Here, the authors show that adhesions are formed through expansive mesothelial membrane bridges, and that blocking these with small molecules prevents formation of adhesions in mice.
