A RELATIONSHIP BETWEEN CARDIAC STRUCTURAL AND FUNCTIONAL PARAMETERS, LEFT VENTRICULAR CONTRACTILITY, AND CORONARY ATHEROSCLEROSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS

Abstract

Objective: to study the association between echocardiographic (EchoCG) parameters in type 2 diabetes mellitus (DM) patients and myocardial contractility and coronary angiographic status as evidenced by ventriculography and coronarography.Material and methods. One hundred and thirty-eight patients with morphologically verified coronary heart disease (CHD), including 74 patients with verified type 2 DM in the study group and 64 patients without carbohydrate metabolic disturbances in the control group, were examined. All the patients underwent EchoCG and coronary angiography with ventriculography. M- and B-mode EchoCG was performed using a GE Vivid 4 ultrasound system (USA).Results. The patients with type 2 DM concurrent with CHD and decreased left ventricular (LV) contractility showed an increase in the number and extent of coronary stenoses and a substantial decrease in LV end-diastolic and end-systolic dimensions, LV mass, and LV mass index. There were statistically significant correlations between diminished left ventricular contractility and main EchoCG parameters.Conclusion. The patients with type 2 DM concurrent with CHD are more frequently observed to have multiple lesions in the coronary arteries (CA), the degree of their stenosis being higher. Cardiac structural and functional remodeling in the patients with type 2 DM was closely related to CA atherosclerotic changes and decreased myocardial contractility.

Keywords

• diabetes mellitus
• myocardial contractility
• myocardial remodeling
• coronary atherosclerosis