Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood

Diptavo Dutta; Yuan He; Ashis Saha; Marios Arvanitis; Alexis Battle; Nilanjan Chatterjee

doi:10.1038/s41467-022-31845-9

Nature Communications (Jul 2022)

Aggregative trans-eQTL analysis detects trait-specific target gene sets in whole blood

Diptavo Dutta,
Yuan He,
Ashis Saha,
Marios Arvanitis,
Alexis Battle,
Nilanjan Chatterjee

Affiliations

Diptavo Dutta: Department of Biostatistics, Johns Hopkins University
Yuan He: Department of Biomedical Engineering, Johns Hopkins University
Ashis Saha: Department of Computer Science, Johns Hopkins University
Marios Arvanitis: Department of Biomedical Engineering, Johns Hopkins University
Alexis Battle: Department of Biomedical Engineering, Johns Hopkins University
Nilanjan Chatterjee: Department of Biostatistics, Johns Hopkins University

DOI: https://doi.org/10.1038/s41467-022-31845-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 14

Abstract

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Large-scale genetic association studies have identified many trait-associated variants that influence gene expression. Here, the authors present ARCHIE, a tool for identifying sets of genes whose regulation may be related to specific complex traits.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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