Frontiers in Oncology (May 2024)

The trend of lymphoma incidence in China from 2005 to 2017 and lymphoma incidence trend prediction from 2018 to 2035: a log-linear regression and Bayesian age-period-cohort analysis

  • Kangqian Lin,
  • Jianjiang Shao,
  • Yuting Cao,
  • Lijun Lu,
  • Peng Lei,
  • Xiaohong Chen,
  • Mengwei Tong,
  • Yaping Lu,
  • Yizhong Yan,
  • Lei Zhang,
  • Xin Pan,
  • Xin Pan,
  • Weixia Nong,
  • Weixia Nong

DOI
https://doi.org/10.3389/fonc.2024.1297405
Journal volume & issue
Vol. 14

Abstract

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ObjectivesThe aims of this study were to explore the incidence characteristics and trend prediction of lymphoma from 2005 to 2035, and to provide data basis for the prevention and control of lymphoma in China.MethodThe data on lymphoma incidence in China from 2005 to 2017 were obtained from the Chinese Cancer Registry Annual Report. The Joinpoint regression model was used to calculate annual percentage change (APC) and average annual percentage change (AAPC) to reflect time trends. Age–period–cohort models were conducted to estimate age, period, and cohort effects on the lymphoma incidence. A Bayesian age–period–cohort model was used to predict lymphoma incidence trends from 2018 to 2035.ResultsFrom 2005 to 2017, the incidence of lymphoma was 6.26/100,000, and the age-standardized incidence rate (ASIR) was 4.11/100,000, with an AAPC of 1.4% [95% confidence interval (CI): 0.3%, 2.5%]. The ASIR was higher in men and urban areas than in women and rural areas, respectively. The age effect showed that the incidence risk of lymphoma increased with age. In the period effect, the incidence risk of lymphoma in rural areas decreased first and then increased with 2010 as the cutoff point. The overall risk of lymphoma incidence was higher in the cohort before the 1970–1974 birth cohort than in the cohort after. From 2018 to 2035, the lymphoma incidence in men, women, and urban areas will show an upward trend.ConclusionFrom 2005 to 2017, the incidence of lymphoma showed an increasing trend, and was different in regions, genders, and age groups in China. It will show an upward trend from 2018 to 2035. These results are helpful for the formulation and adjustment of lymphoma prevention, control, and management strategies, and have important reference significance for the treatment of lymphoma in China.

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