Nature Communications (Nov 2017)

Identification of an analgesic lipopeptide produced by the probiotic Escherichia coli strain Nissle 1917

  • Teresa Pérez-Berezo,
  • Julien Pujo,
  • Patricia Martin,
  • Pauline Le Faouder,
  • Jean-Marie Galano,
  • Alexandre Guy,
  • Claude Knauf,
  • Jean Claude Tabet,
  • Sophie Tronnet,
  • Frederick Barreau,
  • Maud Heuillet,
  • Gilles Dietrich,
  • Justine Bertrand-Michel,
  • Thierry Durand,
  • Eric Oswald,
  • Nicolas Cenac

DOI
https://doi.org/10.1038/s41467-017-01403-9
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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Escherichia coli Nissle is a probiotic that decreases visceral pain associated with irritable bowel syndrome. Here, the authors show that the microbe produces an analgesic lipopeptide, structurally related to GABA, that can cross the gut epithelial barrier and inhibits visceral hypersensitivity in mice.