Microorganisms (May 2024)

<i>Candida auris</i> Outbreaks: Current Status and Future Perspectives

  • Silvia De Gaetano,
  • Angelina Midiri,
  • Giuseppe Mancuso,
  • Maria Giovanna Avola,
  • Carmelo Biondo

DOI
https://doi.org/10.3390/microorganisms12050927
Journal volume & issue
Vol. 12, no. 5
p. 927

Abstract

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Candida auris has been identified by the World Health Organization (WHO) as a critical priority pathogen on its latest list of fungi. C. auris infections are reported in the bloodstream and less commonly in the cerebrospinal fluid and abdomen, with mortality rates that range between 30% and 72%. However, no large-scale epidemiology studies have been reported until now. The diagnosis of C. auris infections can be challenging, particularly when employing conventional techniques. This can impede the early detection of outbreaks and the implementation of appropriate control measures. The yeast can easily spread between patients and in healthcare settings through contaminated environments or equipment, where it can survive for extended periods. Therefore, it would be desirable to screen patients for C. auris colonisation. This would allow facilities to identify patients with the disease and take appropriate prevention and control measures. It is frequently unsusceptible to drugs, with varying patterns of resistance observed among clades and geographical regions. This review provides updates on C. auris, including epidemiology, clinical characteristics, genomic analysis, evolution, colonisation, infection, identification, resistance profiles, therapeutic options, prevention, and control.

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