Vaccines (Jun 2023)

CMC Strategies and Advanced Technologies for Vaccine Development to Boost Acceleration and Pandemic Preparedness

  • Maria Monica Castellanos,
  • Hervé Gressard,
  • Xiangming Li,
  • Claudia Magagnoli,
  • Alessio Moriconi,
  • Daniela Stranges,
  • Laurent Strodiot,
  • Monica Tello Soto,
  • Magdalena Zwierzyna,
  • Cristiana Campa

DOI
https://doi.org/10.3390/vaccines11071153
Journal volume & issue
Vol. 11, no. 7
p. 1153

Abstract

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This review reports on an overview of key enablers of acceleration/pandemic and preparedness, covering CMC strategies as well as technical innovations in vaccine development. Considerations are shared on implementation hurdles and opportunities to drive sustained acceleration for vaccine development and considers learnings from the COVID pandemic and direct experience in addressing unmet medical needs. These reflections focus on (i) the importance of a cross-disciplinary framework of technical expectations ranging from target antigen identification to launch and life-cycle management; (ii) the use of prior platform knowledge across similar or products/vaccine types; (iii) the implementation of innovation and digital tools for fast development and innovative control strategies.

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