Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine

Jing Li; Qingyin Long; Huang Ding; Yang Wang; Dan Luo; Zhou Li; Wei Zhang

doi:10.1002/advs.202308677

Advanced Science (Apr 2024)

Progress in the Treatment of Central Nervous System Diseases Based on Nanosized Traditional Chinese Medicine

Jing Li,
Qingyin Long,
Huang Ding,
Yang Wang,
Dan Luo,
Zhou Li,
Wei Zhang

Affiliations

Jing Li: Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio‐Cerebral Diseases, School of Integrated Chinese and Western Medicine Hunan University of Chinese Medicine Changsha Hunan 410208 China
Qingyin Long: Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio‐Cerebral Diseases, School of Integrated Chinese and Western Medicine Hunan University of Chinese Medicine Changsha Hunan 410208 China
Huang Ding: Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio‐Cerebral Diseases, School of Integrated Chinese and Western Medicine Hunan University of Chinese Medicine Changsha Hunan 410208 China
Yang Wang: Institute of Integrative Medicine Department of Integrated Traditional Chinese and Western Medicine Xiangya Hospital Central South University Changsha Changsha 410008 China
Dan Luo: Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 China
Zhou Li: Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of Sciences Beijing 101400 China
Wei Zhang: Key Laboratory of Hunan Province for Integrated Traditional Chinese and Western Medicine on Prevention and Treatment of Cardio‐Cerebral Diseases, School of Integrated Chinese and Western Medicine Hunan University of Chinese Medicine Changsha Hunan 410208 China

DOI: https://doi.org/10.1002/advs.202308677
Journal volume & issue: Vol. 11, no. 16
pp. n/a – n/a

Abstract

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Abstract Traditional Chinese Medicine (TCM) is widely used in clinical practice to treat diseases related to central nervous system (CNS) damage. However, the blood‐brain barrier (BBB) constitutes a significant impediment to the effective delivery of TCM, thus substantially diminishing its efficacy. Advances in nanotechnology and its applications in TCM (also known as nano‐TCM) can deliver active ingredients or components of TCM across the BBB to the targeted brain region. This review provides an overview of the physiological and pathological mechanisms of the BBB and systematically classifies the common TCM used to treat CNS diseases and types of nanocarriers that effectively deliver TCM to the brain. Additionally, drug delivery strategies for nano‐TCMs that utilize in vivo physiological properties or in vitro devices to bypass or cross the BBB are discussed. This review further focuses on the application of nano‐TCMs in the treatment of various CNS diseases. Finally, this article anticipates a design strategy for nano‐TCMs with higher delivery efficiency and probes their application potential in treating a wider range of CNS diseases.

Published in Advanced Science

ISSN: 2198-3844 (Online)
Publisher: Wiley
Country of publisher: Germany
LCC subjects: Science
Website: https://onlinelibrary.wiley.com/journal/21983844

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Abstract

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