Nature Communications (Oct 2019)

Interleukin 22 disrupts pancreatic function in newborn mice expressing IL-23

  • Lili Chen,
  • Valentina Strohmeier,
  • Zhengxiang He,
  • Madhura Deshpande,
  • Jovani Catalan-Dibene,
  • Scott K. Durum,
  • Thomas M. Moran,
  • Thomas Kraus,
  • Huabao Xiong,
  • Jeremiah J. Faith,
  • Chhinder P. Sodhi,
  • David J. Hackam,
  • Sergio A. Lira,
  • Glaucia C. Furtado

DOI
https://doi.org/10.1038/s41467-019-12540-8
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

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Necrotizing enterocolitis (NEC) is associated with severe neonatal morbidity. Here the authors show, mirroring the NEC phenotype, that IL-23 overexpression in neonates causes malabsorption and decreased expression of intestinal and pancreatic genes mediating food digestion and uptake through IL-22, which directly suppresses pancreatic cell differentiation.