Viruses (Aug 2023)

Characterizing Risk Factors for Hospitalization and Clinical Characteristics in a Cohort of COVID-19 Patients Enrolled in the GENCOV Study

  • Gregory Morgan,
  • Selina Casalino,
  • Sunakshi Chowdhary,
  • Erika Frangione,
  • Chun Yiu Jordan Fung,
  • Simona Haller,
  • Elisa Lapadula,
  • Mackenzie Scott,
  • Dawit Wolday,
  • Juliet Young,
  • Saranya Arnoldo,
  • Navneet Aujla,
  • Erin Bearss,
  • Alexandra Binnie,
  • Yvonne Bombard,
  • Bjug Borgundvaag,
  • Laurent Briollais,
  • Marc Dagher,
  • Luke Devine,
  • Hanna Faghfoury,
  • Steven M. Friedman,
  • Anne-Claude Gingras,
  • Lee W. Goneau,
  • Zeeshan Khan,
  • Tony Mazzulli,
  • Shelley L. McLeod,
  • Romina Nomigolzar,
  • Abdul Noor,
  • Trevor J. Pugh,
  • David Richardson,
  • Harpreet Kaur Satnam Singh,
  • Jared Simpson,
  • Seth Stern,
  • Lisa Strug,
  • Ahmed Taher,
  • Jordan Lerner-Ellis,
  • Jennifer Taher

DOI
https://doi.org/10.3390/v15081764
Journal volume & issue
Vol. 15, no. 8
p. 1764

Abstract

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The GENCOV study aims to identify patient factors which affect COVID-19 severity and outcomes. Here, we aimed to evaluate patient characteristics, acute symptoms and their persistence, and associations with hospitalization. Participants were recruited at hospital sites across the Greater Toronto Area in Ontario, Canada. Patient-reported demographics, medical history, and COVID-19 symptoms and complications were collected through an intake survey. Regression analyses were performed to identify associations with outcomes including hospitalization and COVID-19 symptoms. In total, 966 responses were obtained from 1106 eligible participants (87% response rate) between November 2020 and May 2022. Increasing continuous age (aOR: 1.05 [95%CI: 1.01–1.08]) and BMI (aOR: 1.17 [95%CI: 1.10–1.24]), non-White/European ethnicity (aOR: 2.72 [95%CI: 1.22–6.05]), hypertension (aOR: 2.78 [95%CI: 1.22–6.34]), and infection by viral variants (aOR: 5.43 [95%CI: 1.45–20.34]) were identified as risk factors for hospitalization. Several symptoms including shortness of breath and fever were found to be more common among inpatients and tended to persist for longer durations following acute illness. Sex, age, ethnicity, BMI, vaccination status, viral strain, and underlying health conditions were associated with developing and having persistent symptoms. By improving our understanding of risk factors for severe COVID-19, our findings may guide COVID-19 patient management strategies by enabling more efficient clinical decision making.

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