Prospects for Expanding Drug Therapy for Multiple Drug Resistant and Extensively Drug Resistant Tuberculosis

Abstract

This review analyzes 64 publications on repurposed antibiotics and the prospects of their use in the treatment of multiple drug resistant and extensively drug resistant tuberculosis. The article describes mechanisms of action of beta-lactams and macrolides on tuberculous mycobacteria; the results of studies and safety profiles are given.

Keywords

• микобактерии туберкулеза
• туберкулез легких
• множественная лекарственная устойчивость
• перепрофилирование антибиотиков
• бета-лактамы
• макролиды