Cancer Management and Research (Aug 2021)
The Co-Expression of Melanoma-Antigen Family a Proteins and New York Esophageal Squamous Cell Carcinoma-1 in Breast Cancer: A Pilot Study
Abstract
Yu-Xin Wang,1,* Feng-Lian Li,1,* Li-Xin Du,1 Jun-Fang Liu,2 Li-Gang Huo,1 Shu-Qing Li,3 Bin Tian1 1Department of Clinical Laboratory, Hengshui Fifth People’s Hospital, Hengshui City, 053000, People’s Republic of China; 2Department of Pathology, Hengshui Fifth People’s Hospital, Hengshui City, 053000, People’s Republic of China; 3Department of cardiothoracic surgery, Hengshui Fifth People’s Hospital, Hengshui City, 053000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng-Lian LiDepartment of Clinical Laboratory, Hengshui Fifth People’s Hospital, No. 1638 Shengli West Road, Hengshui City, Hebei Province, 053000, People’s Republic of ChinaTel +86 318-2316645Email [email protected]: The aim of this study was to quantify the expression of melanoma-antigen family A proteins (MAGE-A) and New York esophageal squamous cell carcinoma-1 (NY-ESO-1) in breast cancer and establish the prognosis of breast cancer patients with MAGE-A and NY-ESO-1 co-expression.Methods: A total of 122 patients with breast cancer were recruited for this study. Their clinicopathological data were collected retrospectively, and the MAGE-A and NY-ESO-1 expressions in paraffin-embedded specimens from the 122 patients were evaluated using immunohistochemical analysis. In addition, the survival states of the patients were recorded.Results: Fifty-four patients (44.26%) were MAGE-A positive and 46 (37.70%) were NY-ESO-1 positive. Interestingly, 22 of the 46 NY-ESO-1-positive cases co-expressed MAGE-A. The expression of MAGE-A was positively associated with estrogen-receptor status (χ2 = 4.026, p = 0.045) and human epidermal growth factor receptor 2 status (χ2 = 5.482, p = 0.019), while the expression of NY-ESO-1 was positively associated with p53 expression (χ2 = 4.541, p = 0.033). Of the 122 patients, the lowest survival rate was observed in patients with NY-ESO-1 (+)/MAGE-A (+), with a 5-year survival rate of 59.09% and a median survival of 97 months.Conclusion: The results showed that MAGE-A and NY-ESO-1 were frequently expressed in breast cancer patients. The co-expression of MAGE-A and NY-ESO-1 occurred in about 18% of these patients, and it may indicate a poor prognosis.Keywords: breast cancer, cancer/testis antigens, MAGE-A, NY-ESO-1, co-expression
