Nature Communications (Nov 2022)
Cerebrospinal fluid concentration of complement component 4A is increased in first episode schizophrenia
- Jessica Gracias,
- Funda Orhan,
- Elin Hörbeck,
- Jessica Holmén-Larsson,
- Neda Khanlarkani,
- Susmita Malwade,
- Sravan K. Goparaju,
- Lilly Schwieler,
- İlknur Ş. Demirel,
- Ting Fu,
- Helena Fatourus-Bergman,
- Aurimantas Pelanis,
- Carleton P. Goold,
- Anneli Goulding,
- Kristina Annerbrink,
- Anniella Isgren,
- Timea Sparding,
- Martin Schalling,
- Viviana A. Carcamo Yañez,
- Jens C. Göpfert,
- Johanna Nilsson,
- Ann Brinkmalm,
- Kaj Blennow,
- Henrik Zetterberg,
- Göran Engberg,
- Fredrik Piehl,
- Steven D. Sheridan,
- Roy H. Perlis,
- Simon Cervenka,
- Sophie Erhardt,
- Mikael Landen,
- Carl M. Sellgren
Affiliations
- Jessica Gracias
- Department of Physiology and Pharmacology, Karolinska Institutet
- Funda Orhan
- Department of Physiology and Pharmacology, Karolinska Institutet
- Elin Hörbeck
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Jessica Holmén-Larsson
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Neda Khanlarkani
- Department of Physiology and Pharmacology, Karolinska Institutet
- Susmita Malwade
- Department of Physiology and Pharmacology, Karolinska Institutet
- Sravan K. Goparaju
- Department of Physiology and Pharmacology, Karolinska Institutet
- Lilly Schwieler
- Department of Physiology and Pharmacology, Karolinska Institutet
- İlknur Ş. Demirel
- Department of Physiology and Pharmacology, Karolinska Institutet
- Ting Fu
- Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital
- Helena Fatourus-Bergman
- Department of Clinical Neuroscience, Karolinska Institutet
- Aurimantas Pelanis
- Department of Anesthesiology, Sahlgrenska University Hospital
- Carleton P. Goold
- Novartis Institutes of BioMedical Research
- Anneli Goulding
- Psychosis Clinic, Sahlgrenska University Hospital
- Kristina Annerbrink
- Psychosis Clinic, Sahlgrenska University Hospital
- Anniella Isgren
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Timea Sparding
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Martin Schalling
- Department of Molecular Medicine and Surgery, Karolinska Institutet and Center for Molecular Medicine, Karolinska University Hospital
- Viviana A. Carcamo Yañez
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Jens C. Göpfert
- NMI Natural and Medical Sciences Institute at the University of Tübingen
- Johanna Nilsson
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Ann Brinkmalm
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Kaj Blennow
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Henrik Zetterberg
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Göran Engberg
- Department of Physiology and Pharmacology, Karolinska Institutet
- Fredrik Piehl
- Department of Clinical Neuroscience, Karolinska Institutet
- Steven D. Sheridan
- Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital
- Roy H. Perlis
- Center for Quantitative Health, Center for Genomic Medicine and Department of Psychiatry, Massachusetts General Hospital
- Simon Cervenka
- Department of Clinical Neuroscience, Karolinska Institutet
- Sophie Erhardt
- Department of Physiology and Pharmacology, Karolinska Institutet
- Mikael Landen
- The Institute of Neuroscience and Physiology, University of Gothenburg
- Carl M. Sellgren
- Department of Physiology and Pharmacology, Karolinska Institutet
- DOI
- https://doi.org/10.1038/s41467-022-33797-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
Schizophrenia risk has been associated with the complement component 4 (C4) genes. Here the authors show that C4A is elevated in individuals with schizophrenia.
