CLINICAL AND PROGNOSTIC VALUE OF INTERLEUKIN-12 IN PATIENTS WITH ACUTE MYOCARDIAL INFARCTION

Abstract

Abstract. The aim of present study was to evaluate clinical and prognostic value of various inflammationmarkers in patients after Q-wave myocardial infarction (MI). Results: Among multiple inflammation factors studied, only TNFα, IL-12 and CRP levels proved to be significantly increased in the patients with multi-vesselcoronary artery disease, as compared to the patients with single coronary lesions. A positive correlation was revealed between the levels of IL-12 and IL-6 inflammation markers, and severity of atherosclerotic lesions of non-coronary arteries (brachiocephalic vessels, or lower limb arteries). Regression analysis, using an iterative approach, showed that patients’ age of ≥ 53 years and IL-12 levels ≥ 87.1 pg/ml are of highest predictive value, when detecting clinically significant coronary lesions. Meanwhile, the age of ≥ 65 years and IL- 12 levels exceeding 108.8 pg/ml allow of detecting haemodynamically significant non-coronary lesions. Acute heart failure according to Killip class II and more, and IL-12 levels over 90 pg/ml have been verified as independent variables for risk stratification of any cardiovascular event within a year after MI. Hence, among all studied inflammatory indexes, IL-12 possesses the greatest diagnostic value in defining patients at a high risk for severe coronary and multifocal atherosclerosis and subsequent complications. (Med. Immunol., 2011, vol. 13, N 2-3, pp 219-226)

Keywords

• coronary vessels
• atherosclerosis
• inflammation markers
• il-12
• diagnostic significance