The role of the farnesoid X receptor in kidney health and disease: a potential therapeutic target in kidney diseases

Abstract

Kidney disease: role of key bile acid receptor Targeting the expression and activation of a critical bile acid receptor could be a novel therapeutic approach for kidney diseases. The prevalence of all types of kidney disease is rising due to ageing populations, but there are few therapeutic options available. In a review of recent research, Dong-Hyun Kim, Soo Wan Kim and co-workers at Chonnam National University in Gwangju, South Korea, examined the functional role of a key bile acid receptor protein called farnesoid X (FXR) in health and disease. FXR is widely expressed in the liver, intestines and kidneys, where it maintains bile acid and cholesterol levels, and exerts anti-inflammatory and anti-fibrotic effects. However, existing studies of its role are largely limited to the liver and intestines. The team call for further research into its function in different cell types in the kidney.