Polyurethane Degradable Hydrogels Based on Cyclodextrin-Oligocaprolactone Derivatives
Alexandra-Diana Diaconu,
Corina-Lenuta Logigan,
Catalina Anisoara Peptu,
Constanta Ibanescu,
Valeria Harabagiu,
Cristian Peptu
Affiliations
Alexandra-Diana Diaconu
“Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41A, 700487 Iasi, Romania
Corina-Lenuta Logigan
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 71, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania
Catalina Anisoara Peptu
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 71, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania
Constanta Ibanescu
Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi” Technical University of Iasi, 71, Prof. Dr. Docent Dimitrie Mangeron Street, 700050 Iasi, Romania
Valeria Harabagiu
“Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41A, 700487 Iasi, Romania
Cristian Peptu
“Petru Poni” Institute of Macromolecular Chemistry, Aleea Grigore Ghica Voda 41A, 700487 Iasi, Romania
Polymer networks based on cyclodextrin and polyethylene glycol were prepared through polyaddition crosslinking using isophorone diisocyanate. The envisaged material properties are the hydrophilic character, specific to PEG and cyclodextrins, and the capacity to encapsulate guest molecules in the cyclodextrin cavity through physical interactions. The cyclodextrin was custom-modified with oligocaprolactone to endow the crosslinked material with a hydrolytically degradable character. SEM, DTG, and FTIR characterization methods have confirmed the morphology and structure of the prepared hydrogels. The influence of the crosslinking reaction feed was investigated through dynamic rheology. Further, thermal water swelling and hydrolytic degradation in basic conditions revealed the connectivity of the polymer network and the particular influence of the cyclodextrin amount in the crosslinking reaction feed on the material properties. Also, levofloxacin was employed as a model drug to investigate the drug loading and release capacity of the prepared hydrogels.