Communications Biology (Mar 2021)

Lin28, a major translation reprogramming factor, gains access to YB-1-packaged mRNA through its cold-shock domain

  • Anastasiia Samsonova,
  • Krystel El Hage,
  • Bénédicte Desforges,
  • Vandana Joshi,
  • Marie-Jeanne Clément,
  • Guillaume Lambert,
  • Hélène Henrie,
  • Nicolas Babault,
  • Pierrick Craveur,
  • Rachid C. Maroun,
  • Emilie Steiner,
  • Ahmed Bouhss,
  • Alexandre Maucuer,
  • Dmitry N. Lyabin,
  • Lev P. Ovchinnikov,
  • Loic Hamon,
  • David Pastré

DOI
https://doi.org/10.1038/s42003-021-01862-3
Journal volume & issue
Vol. 4, no. 1
pp. 1 – 16

Abstract

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Samsonova et al. show a cooperative association of Lin28 and YB-1 for their target mRNA through their cold-shock domain, which is a conserved β-barrel structure that binds to single-stranded RNA. This study suggests that the association of Lin28 with YB-1 in mRNPs may contribute to the translational plasticity during development and the adaptation of cancer cells to adverse environments.