Nature Communications (Mar 2016)

Inhibition of IL-1R1/MyD88 signalling promotes mesenchymal stem cell-driven tissue regeneration

  • Mikaël M. Martino,
  • Kenta Maruyama,
  • Gisela A. Kuhn,
  • Takashi Satoh,
  • Osamu Takeuchi,
  • Ralph Müller,
  • Shizuo Akira

DOI
https://doi.org/10.1038/ncomms11051
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 13

Abstract

Read online

TLR and IL-1R1 ligands are danger signals released following tissue injury and during the healing response. Here, the authors show that IL-1β signalling via IL-1R1/MyD88 inhibits the Akt/GSK-3β/β-catenin pathway in mesenchymal stem cells, which suppresses their mobilization, proliferation, and differentiation into osteoblasts, processes necessary for bone regeneration.