Improvement in sleep latency with extended-release once-nightly sodium oxybate for the treatment of adults with narcolepsy: Analysis from the phase 3 REST-ON clinical trial

Michael J. Thorpy; Clete A. Kushida; Richard Bogan; John Winkelman; Maurice M. Ohayon; Colin M. Shapiro; Jennifer Gudeman

Sleep Medicine: X (Dec 2024)

Improvement in sleep latency with extended-release once-nightly sodium oxybate for the treatment of adults with narcolepsy: Analysis from the phase 3 REST-ON clinical trial

Michael J. Thorpy,
Clete A. Kushida,
Richard Bogan,
John Winkelman,
Maurice M. Ohayon,
Colin M. Shapiro,
Jennifer Gudeman

Affiliations

Michael J. Thorpy: Albert Einstein College of Medicine, New York, NY, USA
Clete A. Kushida: Stanford University School of Medicine, Stanford, CA, USA
Richard Bogan: Medical University of South Carolina, Charleston, SC, USA
John Winkelman: Massachusetts General Hospital, Boston, MA, USA
Maurice M. Ohayon: Stanford University School of Medicine, Palo Alto, CA, USA
Colin M. Shapiro: University of Toronto, Toronto, ON, Canada
Jennifer Gudeman: Avadel Pharmaceuticals, Chesterfield, MO, USA; Corresponding author. Medical and Clinical Affairs, Avadel Pharmaceuticals, 16640 Chesterfield Grove Road, Suite 200, Chesterfield, MO, 63005, USA.

Journal volume & issue: Vol. 7
p. 100113

Abstract

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Background: In the REST-ON clinical trial (NCT02720744), mean sleep latency on the Maintenance of Wakefulness Test (MWT) was significantly improved with extended-release once-nightly sodium oxybate (ON-SXB) vs placebo (P 10 % remained awake for the entirety of the MWT. ON-SXB offers a once-at-bedtime treatment option for adults with narcolepsy.

Published in Sleep Medicine: X

ISSN: 2590-1427 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.journals.elsevier.com/sleep-medicine-x

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Abstract

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