Clinics (Jul 2015)

Mean platelet volume is associated with disease severity in patients with obstructive sleep apnea syndrome

  • Selahattin Akyol,
  • Mustafa Çörtük,
  • Ahmet Oytun Baykan,
  • Kemal Kiraz,
  • Abdurrezzak Börekçi,
  • Taner Şeker,
  • Mustafa Gür,
  • Murat Çayli

DOI
https://doi.org/10.6061/clinics/2015(07)04
Journal volume & issue
Vol. 70, no. 7
pp. 481 – 485

Abstract

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OBJECTIVE: Obstructive sleep apnea syndrome is associated with cardiovascular diseases and thromboembolic events. The mean platelet volume (MPV) is a predictor of cardiovascular thromboembolic events. The aim of the present study is to investigate the association between the MPV and disease severity in patients with obstructive sleep apnea syndrome. METHODS: We prospectively included 194 obstructive sleep apnea syndrome patients without cardiovascular disease (mean age 56.5±12.5 years) who were undergoing sleep tests. An overnight full laboratory polisomnography examination was conducted on each patient. The patients were divided into 3 groups according to the apnea-hypopnea index (AHI): (1) AHIlow group: 5≤AHI30. RESULTS: The highest MPV values were found in the AHIhigh group compared with other groups (p<0.05 for all). Multiple linear regression analysis indicated that the MPV was associated with the AHI (β=0.500, p<0.001) and the high sensitivity C-reactive protein (hs-CRP) level (β=0.194, p=0.010). CONCLUSION: The MPV is independently associated with both disease severity and inflammation in patients with obstructive sleep apnea syndrome.

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