Sirt6 reprograms myofibers to oxidative type through CREB-dependent Sox6 suppression

Abstract

Exercise is helpful to counteract obesity and the related complications, and positive effects are associated to a switch of muscle fibres to an oxidative type. Here, the authors show that sirtuin 6 overexpression in mice induces such a switch by modulating Sox6 and CREB signalling, suggesting that sirtuin 6 may be a target for exercise mimetics.