Viruses
(Dec 2018)
Development of Small-Molecule MERS-CoV Inhibitors
Ruiying Liang,
Lili Wang,
Naru Zhang,
Xiaoqian Deng,
Meng Su,
Yudan Su,
Lanfang Hu,
Chen He,
Tianlei Ying,
Shibo Jiang,
Fei Yu
Affiliations
Ruiying Liang
College of Life and Science, Hebei Agricultural University, Baoding 071001, China
Lili Wang
Research Center of Chinese Jujube, Hebei Agricultural University, Baoding 071001, China
Naru Zhang
Department of Clinical Medicine, Faculty of Medicine, Zhejiang University City College, Hangzhou 310015, China
Xiaoqian Deng
College of Life and Science, Hebei Agricultural University, Baoding 071001, China
Meng Su
College of Life and Science, Hebei Agricultural University, Baoding 071001, China
Yudan Su
College of Life and Science, Hebei Agricultural University, Baoding 071001, China
Lanfang Hu
College of Life and Science, Hebei Agricultural University, Baoding 071001, China
Chen He
College of Life and Science, Hebei Agricultural University, Baoding 071001, China
Tianlei Ying
Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Shibo Jiang
Key Laboratory of Medical Molecular Virology of MOE/MOH, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Fei Yu
College of Life and Science, Hebei Agricultural University, Baoding 071001, China
DOI
https://doi.org/10.3390/v10120721
Journal volume & issue
Vol. 10,
no. 12
Abstract
Read online
Middle East respiratory syndrome coronavirus (MERS-CoV) with potential to cause global pandemics remains a threat to the public health, security, and economy. In this review, we focus on advances in the research and development of small-molecule MERS-CoV inhibitors targeting different stages of the MERS-CoV life cycle, aiming to prevent or treat MERS-CoV infection.
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