Nature Communications (Feb 2017)
Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma
- Shawn T. Beug,
- Caroline E. Beauregard,
- Cristin Healy,
- Tarun Sanda,
- Martine St-Jean,
- Janelle Chabot,
- Danielle E. Walker,
- Aditya Mohan,
- Nathalie Earl,
- Xueqing Lun,
- Donna L. Senger,
- Stephen M. Robbins,
- Peter Staeheli,
- Peter A. Forsyth,
- Tommy Alain,
- Eric C. LaCasse,
- Robert G. Korneluk
Affiliations
- Shawn T. Beug
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Caroline E. Beauregard
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Cristin Healy
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Tarun Sanda
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Martine St-Jean
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Janelle Chabot
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Danielle E. Walker
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Aditya Mohan
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Nathalie Earl
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Xueqing Lun
- Arnie Charbonneau Cancer Institute, University of Calgary
- Donna L. Senger
- Arnie Charbonneau Cancer Institute, University of Calgary
- Stephen M. Robbins
- Arnie Charbonneau Cancer Institute, University of Calgary
- Peter Staeheli
- Institute of Virology, University Medical Center Freiburg
- Peter A. Forsyth
- H. Lee Moffit Cancer Center and Research Institute
- Tommy Alain
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Eric C. LaCasse
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- Robert G. Korneluk
- Apoptosis Research Centre, Children's Hospital of Eastern Ontario Research Institute
- DOI
- https://doi.org/10.1038/ncomms14278
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 15
Abstract
Smac mimetics sensitize cancer cells to the extrinsic cell death pathway and stimulate anti-tumour immunity. In this study, the authors show that Smac mimetics can synergize with immune checkpoint inhibitors to control tumour growth in mouse cancer models, including aggressive CNS tumours, in a cytotoxic CD8+T-cell- and TNFα-dependent manner.
