Nature Communications (Oct 2022)
TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine composition and promote the progression of non-alcoholic steatohepatitis
- Kasparas Petkevicius,
- Henrik Palmgren,
- Matthew S. Glover,
- Andrea Ahnmark,
- Anne-Christine Andréasson,
- Katja Madeyski-Bengtson,
- Hiroki Kawana,
- Erik L. Allman,
- Delaney Kaper,
- Martin Uhrbom,
- Liselotte Andersson,
- Leif Aasehaug,
- Johan Forsström,
- Simonetta Wallin,
- Ingela Ahlstedt,
- Renata Leke,
- Daniel Karlsson,
- Hernán González-King,
- Lars Löfgren,
- Ralf Nilsson,
- Giovanni Pellegrini,
- Nozomu Kono,
- Junken Aoki,
- Sonja Hess,
- Grzegorz Sienski,
- Marc Pilon,
- Mohammad Bohlooly-Y,
- Marcello Maresca,
- Xiao-Rong Peng
Affiliations
- Kasparas Petkevicius
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Henrik Palmgren
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Matthew S. Glover
- Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca
- Andrea Ahnmark
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Anne-Christine Andréasson
- Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Katja Madeyski-Bengtson
- Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca
- Hiroki Kawana
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Erik L. Allman
- Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca
- Delaney Kaper
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Martin Uhrbom
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Liselotte Andersson
- Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca
- Leif Aasehaug
- Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Johan Forsström
- Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca
- Simonetta Wallin
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Ingela Ahlstedt
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Renata Leke
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Daniel Karlsson
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Hernán González-King
- Bioscience Cardiovascular, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Lars Löfgren
- Translational Science and Experimental Medicine, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Ralf Nilsson
- Translational Science and Experimental Medicine, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- Giovanni Pellegrini
- Clinical Pharmacology and Safety Sciences, BioPharmaceuticals R&D, AstraZeneca
- Nozomu Kono
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Junken Aoki
- Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo
- Sonja Hess
- Dynamic Omics, Centre for Genomics Research, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca
- Grzegorz Sienski
- Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca
- Marc Pilon
- Department of Chemistry and Molecular Biology, University of Gothenburg
- Mohammad Bohlooly-Y
- Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca
- Marcello Maresca
- Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca
- Xiao-Rong Peng
- Bioscience Metabolism, Research and Early Development Cardiovascular, Renal and Metabolism, BioPharmaceuticals R&D, AstraZeneca
- DOI
- https://doi.org/10.1038/s41467-022-33735-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 14
Abstract
The regulation of cellular phosphatidylethanolamine (PE) acyl chain composition is poorly understood. Here, the authors show that TLCD1 and TLCD2 proteins mediate the formation of monounsaturated fatty acid-containing PE species and promote the progression of non-alcoholic steatohepatitis.
