Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

W. Michael Babinchak; Benjamin K. Dumm; Sarah Venus; Solomiia Boyko; Andrea A. Putnam; Eckhard Jankowsky; Witold K. Surewicz

doi:10.1038/s41467-020-19211-z

Nature Communications (Nov 2020)

Small molecules as potent biphasic modulators of protein liquid-liquid phase separation

W. Michael Babinchak,
Benjamin K. Dumm,
Sarah Venus,
Solomiia Boyko,
Andrea A. Putnam,
Eckhard Jankowsky,
Witold K. Surewicz

Affiliations

W. Michael Babinchak: Department of Physiology and Biophysics, Case Western Reserve University
Benjamin K. Dumm: Department of Physiology and Biophysics, Case Western Reserve University
Sarah Venus: Center for RNA Science & Therapeutics, Case Western Reserve University
Solomiia Boyko: Department of Physiology and Biophysics, Case Western Reserve University
Andrea A. Putnam: Center for RNA Science & Therapeutics, Case Western Reserve University
Eckhard Jankowsky: Center for RNA Science & Therapeutics, Case Western Reserve University
Witold K. Surewicz: Department of Physiology and Biophysics, Case Western Reserve University

DOI: https://doi.org/10.1038/s41467-020-19211-z
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Dysregulated liquid-liquid phase separation (LLPS) of proteins can facilitate aberrant phase transitions and lead to protein aggregation and disease. Here, authors demonstrate that 4,4’-dianilino-1,1’-binaphthyl-5,5’-disulfonic acid (bis-ANS) and similar compounds are potent biphasic modulators of protein LLPS.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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