Replication stress increases mitochondrial metabolism and mitophagy in FANCD2 deficient fetal liver hematopoietic stem cells

• Makiko Mochizuki-Kashio,
• Noriko Otsuki,
• Kota Fujiki,
• Sherif Abdelhamd,
• Peter Kurre,
• Markus Grompe,
• Atsushi Iwama,
• Kayoko Saito,
• Ayako Nakamura-Ishizu

Affiliations

Makiko Mochizuki-Kashio

Department of Mieroscopic and Developmental Anatomy, Tokyo Women’s Medical University, Tokyo, Japan

Noriko Otsuki

Institute of Medical Genetics, Tokyo Women’s Medical University, Tokyo, Japan

Kota Fujiki

Department of Hygiene and Fublic Health, Tokyo Women’s Medical University, Tokyo, Japan

Sherif Abdelhamd

Department of Pathology, St. Jude Children’s Research Hospital, Memphis, TN, United States

Peter Kurre

Children’s Hospital of Philadelphia, Comprehensive Bone Marrow Failure Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Markus Grompe

Papé Family Pediatric Research Institute, Oregon Stem Cell Center, Oregon Health & Science University, Portland, OR, United States

Atsushi Iwama

Division of Stem Cell and Molecular Medicine, Center for Stem Cell Biology and Regenerative Medicine, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Kayoko Saito

Institute of Medical Genetics, Tokyo Women’s Medical University, Tokyo, Japan

Ayako Nakamura-Ishizu

Department of Mieroscopic and Developmental Anatomy, Tokyo Women’s Medical University, Tokyo, Japan