Targeting AMP-activated protein kinase in sepsis

Tetsuya Yumoto; Tetsuya Yumoto; Craig M. Coopersmith

doi:10.3389/fendo.2024.1452993

Frontiers in Endocrinology (Oct 2024)

Targeting AMP-activated protein kinase in sepsis

Tetsuya Yumoto,
Tetsuya Yumoto,
Craig M. Coopersmith

Affiliations

Tetsuya Yumoto: Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, United States
Tetsuya Yumoto: Department of Emergency, Critical Care and Disaster Medicine, Faculty of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
Craig M. Coopersmith: Department of Surgery and Emory Critical Care Center, Emory University School of Medicine, Atlanta, GA, United States

DOI: https://doi.org/10.3389/fendo.2024.1452993
Journal volume & issue: Vol. 15

Abstract

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Sepsis is a global health challenge marked by limited clinical options and high mortality rates. AMP-activated protein kinase (AMPK) is a cellular energy sensor that mediates multiple crucial metabolic pathways that may be an attractive therapeutic target in sepsis. Pre-clinical experimental studies have demonstrated that pharmacological activation of AMPK can offer multiple potential benefits during sepsis, including anti-inflammatory effects, induction of autophagy, promotion of mitochondrial biogenesis, enhanced phagocytosis, antimicrobial properties, and regulation of tight junction assembly. This review aims to discuss the existing evidence supporting the therapeutic potential of AMPK activation in sepsis management.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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Abstract

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